4-HYDROXY-2- QUINOLONES 199~*. USE OF N,N'-DICYCLOHEXYLCARBODIIMIDE IN THE SYNTHESIS OF ETHYL 4-HYDROXY-2-OXO- 1,2-DIHYDROQUINOLINE-3-CARBOXYLATES

摘要

A novel method has been developed for the synthesis of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids esters based on the use of monoethyl malonate as an acylating agent in the presence of N,N'-dicyclohexylcarbodiimide and characterized by high yields and purity for the final products. Practical recommendations are given for the removal of specific admixtures.