Genetic Markers of Human Evolution Are Enriched in Schizophrenia

Srinivasan Saurabh; Bettella Francesco; Mattingsdal Morten; Wang Yunpeng; Witoelar Aree; Schork Andrew J.; Thompson Wesley K.; Zuber Verena; Winsvold Bendik S.; Zwart John-Anker; Collier David A.; Desikan Rahul S.; Melle Ingrid; Werge Thomas; Dale Anders M.; Djurovic Srdjan; Andreassen Ole A.

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Genetic Markers of Human Evolution Are Enriched in Schizophrenia

机译：精神分裂症丰富了人类进化的遗传标记

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BACKGROUND: Why schizophrenia has accompanied humans throughout our history despite its negative effect on fitness remains an evolutionary enigma. It is proposed that schizophrenia is a by-product of the complex evolution of the human brain and a compromise for humans' language, creative thinking, and cognitive abilities.

机译：背景：尽管精神分裂症对健身有负面影响，但为什么精神分裂症在人类的整个历史中始终伴随着人类进化。有人认为精神分裂症是人脑复杂进化的副产物，是人类语言，创造性思维和认知能力的折衷。

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《Biological psychiatry》 |2016年第4期|共9页
作者
Srinivasan Saurabh; Bettella Francesco; Mattingsdal Morten; Wang Yunpeng; Witoelar Aree; Schork Andrew J.; Thompson Wesley K.; Zuber Verena; Winsvold Bendik S.; Zwart John-Anker; Collier David A.; Desikan Rahul S.; Melle Ingrid; Werge Thomas; Dale Anders M.; Djurovic Srdjan; Andreassen Ole A.;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Evolution; GWAS; Human; Neanderthal; Polygenic; Schizophrenia;

机译：进化;GWAS;人类;尼安德特人;多基因;精神分裂症;

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专利

1. Genetic Markers of Human Evolution Are Enriched in Schizophrenia [J] . Srinivasan Saurabh, Bettella Francesco, Mattingsdal Morten, Biological psychiatry . 2016,第4期

机译：精神分裂症丰富了人类进化的遗传标记
2. Enrichment of genetic markers of recent human evolution in educational and cognitive traits [J] . Saurabh Srinivasan, Francesco Bettella, Oleksandr Frei, Scientific reports. . 2018,第1期

机译：在教育和认知特质中丰富最近人类进化的遗传标记
3. The role of genes affected by human evolution marker GNA13 in schizophrenia [J] . Xiang Bo, Yang Juanjuan, Zhang Jin, Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal . 2020,第期

机译：受人类演化标志物GNA13在精神分裂症中影响的基因的作用
4. Identification and phylogenetic analysis of schizophrenia associated retrovirus (SZRV) element in the human GenBank database [C] . Jun-Seop Kim, Sang-Bae Kim, InSong Koh Workshop on Genome Informatics . 2001

机译：人纳银行数据库中精神分裂症相关逆转录病毒（SZRV）元素的鉴定和系统发育分析
5. Functional and structural brain markers of the genetic vulnerability to schizophrenia: A neuroimaging investigation of schizophrenia patients, non -psychotic adult relatives, and community ontrols. [D] . Goghari, Vina Mahesh. 2009

机译：精神分裂症遗传易感性的功能性和结构性脑标志物：对精神分裂症患者，非精神病成年亲属和社区存在的神经影像学调查。
6. Genetic markers of human evolution are enriched in schizophrenia [O] . Saurabh Srinivasan, Francesco Bettella, Morten Mattingsdal, -1

机译：人类进化的遗传标志物富含精神分裂症
7. Genetic markers of human evolution are enriched in schizophrenia [O] . Srinivasan, Saurabh, Bettella, Francesco, Henskens, Frans A., 2016

机译：人类进化的遗传标志物富含精神分裂症

Genetic Markers of Human Evolution Are Enriched in Schizophrenia

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