Histidine and thermal copolymers of amino acids containing histidine as prebiotic inhibitor for the template-directed formation of oligoguanylate on a poly(C) template

摘要

Possibility of the cooperative chemical evolution of nucleic acids and proteins has been investigated using the templatedirected formation of oligoguanylate with amino acids and thermal copolymers of amino acids, in which strong inhibition by histidine containing thermal copolymer and histidine itself was observed. The inhibition is regarded as prebiotic enzymatic activities for the hydrolysis of activated nucleotide monomer and the formation of pyrophospho-capped oligoguanylate.