Diastereoselective Pinacol Coupling Reaction of Aliphatic and Aromatic Aldehydes Promoted by Low Valent Titanium Iodide in site Formed by Titanium (IV)Iodide and Copper

摘要

The pinacol coupling reaction of aromatic and aliphatic aldehydes including pivalaldehyde with low valent titanium iodide,in site formed from titanium iodide (IV) and copper,proceeded smoothly in a mixed solvent of dichloromethane and pivalonitrile to give the corresponding 1,2-diols in good to high yields and dl-selectivities.