Safety and efficacy of measles, mumps, and rubella vaccine in patients with DiGeorge syndrome.

摘要

DiGeorge syndrome is the most common cause of T-cell lymphocytopenia in infants, affecting 1 in 3000 children. More than 90% of these patients have a microdeletion in 22qll.2 chromosome, which can cause an array of clinical features, including cardiac and neurologic anomalies in addition to an underdeveloped thymus gland.Most patients with 22qll.2 microdeletion have reduced numbers of circulating T cells that gradually increase with time, frequently providing these patients with adequate protection from infections. One of the critical questions in the management of 22qll.2 microdeletion is the safety and efficacy of live vaccines in view of their immunodeficiency.