C5a decoy receptor

摘要

Degradation products of complement factors C3, C4, and C5 (known as anaphylatoxins) mediate a variety of proinflammatory functions including chemotaxis,cellular activation, and vascular leakage. As such, they influence a variety of disease states including asthma. C5L2 is a serpentine receptor homologous and coex-pressed with the C5a receptor on many cells including neutrophils; however, its function is enigmatic because it does not appear to effectively couple with G proteins even though it efficiently binds C5a. To address the