Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84

摘要

Type 2 innate lymphoid cells (ILC2s) have recently been discovered and include nuocytes, natural helper cells, and innate type 2 helper cells.DLC2s do not express known surface markers for T, B, natural killer, or natural killer T cells (lineage-negative) and produce large amounts of TH2 cytokines in response to cytokines EL-33, IL-25, thymic stromal lympho-poietin, and leukotriene D4.Studies in animal models have shown that ILC2s contribute to allergen-induced airway hyperres-ponsiveness and type 2 lung inflammatory responses, suggesting that ILC2s may have a role in asthma and allergic disease. Human ILC2s have been detected in peripheral blood, gastrointestinal tract, lung, bronchoalveolar lavage, and nasal polyps and are defined as lineage-negative lymphocytes that express the chemoattractant receptor homologous molecule expressed on TH2 lymphocytes (CRTH2).5 We have previously reported that peripheral blood ILC2s highly express the master TH2 cytokine transcription factor GATA-binding protein 3, supporting a role for rapid ILC2 TH2 cytokine production.