Facile Synthesis of Optically Active Tertiary Alcohol Building Blocks by Stereospecific C-H Insertion Reaction of Dichlorocarbene with Secondary Alcohol Derivatives

摘要

Stereospecific C-H insertion of dichlorocarbene generated from a system CHCl_3/50%NaOH/cetyltrimethylammonium chloride (as a PTC) proceeded at the carbinol carbonin the reaction of chiral secondary alcohol derivatives to provide #alpha#-dichloromethylated etrtiary alcohol derivatives with complete retention of configuration