Superiority of the carbamoylmethyl ester as an acyl donor for the protease-catalyzed kinetically controlled peptide synthesis in organic media: Application to segment condensations

摘要

The superiority of the carbamoylmethyl ester as an acyl donor for the alpha-chymotrypsin-catalyzed kinetically controlled peptide synthesis was demonstrated in several segment condensations carried out in organic media with low water content. Then this approach was successfully applied to the construction of the Leu-enkephalin sequence via the 4 + 1 segment condensation. [References: 6]