Synthesis of Iron(III) Complex Bearing Tridentate β-Aminoketonato Ligand: Application to Iron-catalyzed Cross-coupling Reaction of Arylmagnesium Bromides with Alkyl Halides

摘要

A tridentate β-aminoketonato iron complex was prepared by the reaction of lithium β-aminoketonato with FeCl3. This iron complex was found to be an efficient catalyst for the cross-coupling reaction between arylmagnesium bromides and alkyl halides. Transition-metal-catalyzed C-C bond formation between organometallic reagents and organic halides is one of the most important reactions in modern organic synthesis. Various transition metals have been employed as an efficient catalyst for the reaction, for example, Pd, Ni, and Co. Recently, iron complexes have been actively investigated as a catalyst in the reaction, because iron is a nearly ideal transition metal due to its low cost, nontoxicity, and availability. It has been reported