Iron(III) Chloride-catalyzed Nucleophilic Substitution of Propargylic Alcohols: A General and Efficient Approach for the Synthesis of 1,4-Diynes

摘要

A wide variety of 1,4-diynes have been constructed via a novel FeCl3-catalyzed coupling reaction of propargylic alcohols with alkynylsilanes. This synthetic approach provides a general, efficient, and economical route to 1,4-diynes.