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首页> 外文期刊>The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease >Bone marrow cultures for the diagnosis of mycobacterial and fungal infections in patients infected with the human immunodeficiency virus.
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Bone marrow cultures for the diagnosis of mycobacterial and fungal infections in patients infected with the human immunodeficiency virus.

机译:骨髓培养物用于诊断感染了人类免疫缺陷病毒的患者的分枝杆菌和真菌感染。

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摘要

SETTING: University medical center. OBJECTIVE: To determine the value of bone marrow cultures for mycobacteria and fungi in patients infected with the human immunodeficiency virus (HIV). DESIGN: Retrospective review of charts and laboratory records. RESULTS: From 1992-1996, 1225 bone marrow specimens were submitted for mycobacterial and fungal cultures. The number of specimens submitted,declined sharply from 435 in 1992 to 94 in 1996 (P = 0.002 for trend). The yield remained stable. Thirty-one of 1225 specimens grew mycobacteria or fungi; 26 isolates were from 24 HIV-infected patients. These 24 patients were infected with Mycobacterium avium complex (19), M. tuberculosis (one), M. chelonae (one), Histoplasma capsulatum (two), and Cryptococcus neoformans (one). All 24 HIV-infected patients had a culture submitted from at least one other site within 4 weeks of the positive bone marrow culture. The identical organism was grown from another site (usually blood) in 18 of these 24 patients. The bone marrow culture provided the only positive result in six patients and the first positive result in eight patients. CONCLUSIONS: Utilization of bone marrow cultures for mycobacteria and fungi declined at our institution. Bone marrow and blood cultures were highly concordant. However, the majority of positive bone marrow cultures provided useful information.
机译:地点:大学医学中心。目的:确定骨髓培养物对人免疫缺陷病毒(HIV)感染患者的分枝杆菌和真菌的价值。设计:回顾性检查图表和实验室记录。结果:从1992年至1996年,共提交了1225份骨髓标本用于分枝杆菌和真菌培养。提交的标本数量从1992年的435个急剧下降到1996年的94个(趋势P = 0.002)。产量保持稳定。 1225个标本中有31个生长了分枝杆菌或真菌。来自24名HIV感染患者的26株分离株。这24例患者感染了鸟分枝杆菌复合体(19),结核分枝杆菌(1),开胃支原体(1),荚膜组织胞浆菌(2)和新隐球菌(1)。所有24名受HIV感染的患者在阳性骨髓培养后4周内均从至少一个其他部位进行了培养。在这24名患者中的18名患者中,同一生物是从另一个部位(通常是血液)生长而来的。骨髓培养在6例患者中提供了唯一的阳性结果,而在8例中提供了第一个阳性结果。结论:在我们机构中,骨髓培养物对分枝杆菌和真菌的利用下降。骨髓和血液培养高度一致。但是,大多数阳性骨髓培养物提供了有用的信息。

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