In Vivo Ketamine-Induced Changes in [C-11] ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5

摘要

BACKGROUND: At subanesthetic doses, ketamine, an N-methyl-D-aspartate glutamate receptor antagonist, increases glutamate release. We imaged the acute effect of ketamine on brain metabotropic glutamatergic receptor subtype 5 with a high-affinity positron emission tomography (PET) ligand [C-11]ABP688 (E)-3-[2-(6-methyl-2-pyridinyl) ethynyl]-2-cyclohexen-1-one-O-(methyl-C-11) oxime, a negative allosteric modulator of the metabotropic glutamatergic receptor subtype 5.