Efficient Method for Dehydration Condensation Using Pyridine-3-carboxyIic Anhydride (3-PCA):Synthesis of Carboxamides from Nearly Equimolar Amounts of Carboxylic Acids and Amines

摘要

A highly useful method for the preparation of carboxamides from various carboxylic acids and amines is established by using pyridine-3-carboxylic anhydride (3-PCA) in the presence of 4-(dimethylamino)pyridine (DMAP). This reaction proceeds smoothly under mild conditions by simple experimental proce dure.