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Can continuing benzodiazepine use be predicted?

机译:可以预测继续使用苯二氮卓类药物吗?

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The objective of the present study was to examine characteristics of benzodiazepine (BZD) users, as well as try to identify predictors of continuing BZD use. Health-related data were collected twice on the same sample of Canadians two years apart. Drug use was based on the question: What medications did you take over the last two days? variables used were age, sex, education, marital status, chronic conditions, non-BZD drug use, health status and pain level. Of the 11,624 respondents, 371 (3.2%) reported taking BZDs in 1994. Logistic regression results showed that the highest odds of BZD use were for antidepressant users (OR=10.7, P<0.05), followed by poor health (OR=5.0, P<0.05), pain (OR=3.9, P<0.05) and chronic conditions (OR=3.2, P<0.05). Of the 371 individuals who reported BZD use in 1994, 198 (53.4%) reported BZD use in 1996. Logistic regression showed that none of the variables mentioned above showed a significant association with continuing (including gaps in use) BZD use in 1996. Regarding individual BZDs, it could not be concluded definitively that any BZD is more likely to show continued use than any other, but the possibility of a linear relationship between the proportion of continued use and the half-life of the BZD should be investigated further. Thus, the main predictive factor for continuing use of BZD, as shown by this study, is that of previous use. Whenever a BZD is prescribed, regardless of whether it is a new or repeat prescription, it should be remembered that the likelihood of continuing use is considerable.
机译:本研究的目的是检查苯二氮卓(BZD)用户的特征,并尝试确定BZD持续使用的预测因素。与健康相关的数据每两年间隔两次在同一加拿大人样本中收集到。吸毒是基于以下问题:您在过去两天服用了哪些药物?使用的变量是年龄,性别,教育程度,婚姻状况,慢性病,非BZD药物使用,健康状况和疼痛程度。在11,624名受访者中,有371名(3.2%)报告在1994年服用BZD。Logistic回归结果显示,使用BZD的几率最高是抗抑郁药使用者(OR = 10.7,P <0.05),其次是健康状况不佳(OR = 5.0, P <0.05),疼痛(OR = 3.9,P <0.05)和慢性病(OR = 3.2,P <0.05)。在1994年报告使用BZD的371个人中,有198人(53.4%)在1996年报告了BZD的使用。Logistic回归显示,上述变量均与1996年BZD的持续使用(包括使用差距)没有显着相关性。对于单个BZD,无法确切地得出结论,任何BZD都比其他任何BZD更可能显示出持续使用,但是应进一步研究持续使用的比例与BZD的半衰期之间存在线性关系的可能性。因此,如本研究所示,继续使用BZD的主要预测因素是以前的使用。无论何时开出BZD处方,无论是新处方还是重复处方,都应记住继续使用的可能性相当大。

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