TNF-alpha level and metabolic status in a-tocopheryl acetate supplemented high body condition periparturient crossbred cows during summer and winter

摘要

The study was conducted to investigate the effect of a-tocopheryl acetate supplementation on tumor necrosis factor-alpha (TNF- alpha) level and metabolic status in periparturient crossbred cows during summer and winter. High body condition periparturient crossbred cows (24) were selected, 12 each during summer and winter. For each season, 6 cows were kept as controls and 6 cows were supplemented with alpha-tocopherol acetate @ 1000IU/ day/ cow, supplementation beginning 60 days prior to the expecteddate of calving. Blood samples were collected at -20, -10, -5, 0, 5, 10 and 20 days in relation to expected date of calving. Glucose value observed higher in winter treatment than other group cows. Non-esterified fatty acid concentration levels increasedtowards calving and were higher at day 5 postpartum in summer control in comparison to all other groups. Plasma TNF-alpha levels also increased toward calving but were higher at the day of calving, after that levels decreased towards day 20 postpartum in all the groups. The study indicated that metabolic statuses of high body condition crossbred cows were improved by supplementation of alpha-tocopherol acetate.