EFFECT OF SYSTEMIC AND INTRAUTERINE ADMINISTRATION OFDRUG ON ENDOMETRITIS IN COW

摘要

A total of 18 selected cows with endometritis were randomly allocated to 3 groups, comprising of 6 animals in each group. Ceftriaxone sodium at a dose rate of 10 mg/kg body weight was administered only once through I.V., I.M. and I.U. routes to each of 6 animals in different groups. Efficacy of the treatment of endometritis with Ceftriaxone was judged on the basis of bacteriological record. The average bacterial colonies count recorded was 247.66 X 10~6 /ml of uterine fluid before treatment in all groups. The mean bacterial colony counts per ml of uterine fluid decreased to the minimum (4.00 ± 0.36 X10~6 /ml) 3 hours after I. V, 1 hour (5.33±0.55X 10~6/ml) after I.U and 6 hours (5.33±0.66 X 10~6 /ml) after I.M. administration of drug and again increased gradually reaching to 56.66 +1.80 X10~6 /ml, 85.33 ±2.78 X10~6 /ml and 81.16 ± 1.24 X10~6 /ml of uterine fluid , respectively at 72 hours. The estrual discharge was mucopurulent before treatment & became clear after treatment. Before treatmentall the endometritic cows were positive to white side test which became negative post treatment.