Manganese(II) chloride-catalyzed alkylmagnesation of 2-alkynylphenol

摘要

Treatment of 2-alkynylphenol with an alkyl Grignard reagent in the presence of a catalytic amount of manganese(II) chloride provided 2-(2-alkyl-1-alkenyl)phenol in good yield. Alkylmagnesation proceeded with high region- and stereoselectivities. [References: 14]