CARDIOPROTECTIVE EFFECTS OF PROTEIN POWDER SUPPLEMENTED WITH GRAPE SEED EXTRACT AND CO ENZYME 910 ON ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS

摘要

Globally millions of people are affected by cardiac diseases. Myocardial ischemia is one of the serious cardiac related disorders. Myocardial Infarction (Ml) accounts for majority of cardiac deaths and disabilities. In spite of the availability of thedrugs for the treatment of cardiac diseases, they have posed a big challenge for their treatment. The use of complementary and alternative medicines is burgeoning globally for Ml. Isoproterenol (ISP), a synthetic catecholamine and d-adrenergic agonist that causes severe stress in myocardium and infarct-like necrosis of the heart muscles. ISP induced myocardial injury involves membrane permeability alterations, which brings about the loss of functions and integrity of myocardial membranes. ISP induced myocardial necrosis is a well known standard model to study the beneficial effect of many drugs on cardiac dysfunction. The present investigation was undertaken to evaluate the cardioprotective activity of protein powder supplemented with grape seed extract and co enzyme Q10 in isoprenaline-induced cardiac damage in rats and to understand the molecular mechanism of its therapeutic effect with reference to cardiac markers and lipid profiles.