Structure-activity relationship of insulinomimetic activity of zinc(II) complexes with pyridine-2-sulfonic acid derivatives

摘要

We prepared zinc(II) complexes with a series of monomethyl- substituted pyridine-2-sulfonic acid derivatives to clarify the relationship between the structure and insulinomimetic activity. Towards in vitro insulmornimetic activity, bis(3-methylpyridine-2-sulfonato)zinc(II) gave the best result among the zinc(II) complexes with methylpyridine-2-sulfonates.