Adverse Effects of beta-Blocker Therapy on Weight Loss in Response to a Controlled Dietary Regimen

摘要

Background: The effects of beta-blockers on metabolic parameters including weight loss are poorly understood. Methods: From a database of 3582 patients who completed The Ottawa Hospital Weight Management Program between 1992 and 2011, a total of 173 patients were receiving beta-blockers and were eligible for the study. We determined differences in rate of weight loss in the first 6 weeks of this 900 kcal/d Optifast (Nestle Health Science, Vevey, Switzerland) meal replacement program for patients treated with beta-blockers compared with (1) matched controls and (2) all participants in the program not being treated with beta-blockers. Secondary outcomes included changes in waist circumference.