Nicotine Induces Cardiomyocyte Hypertrophy Through TRPC3-Mediated Ca2+/NFAT Signalling Pathway

Li Na; Si Biao; Ju Ji-Feng; Zhu Meng; You Feng; Wang Dong; Ren Jie; Ning Yan-Song; Zhang Feng-Quan; Dong Kai; Huang Jing; Yu Wen-Qian; Wang Tong-Jian; Qiao Bin

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Nicotine Induces Cardiomyocyte Hypertrophy Through TRPC3-Mediated Ca2+/NFAT Signalling Pathway

机译：尼古丁通过TRPC3介导的Ca2 + / NFAT信号通路诱导心肌肥大

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Background: Nicotine is thought to be an important risk factor for the development of cardiovascular diseases. However, the effects of nicotine on cardiomyocyte hypertrophy are poorly understood. The present study was designed to explore the role of nicotine in cardiomyocyte hypertrophy and its underlying mechanism.

机译：背景：尼古丁被认为是发展心血管疾病的重要危险因素。然而，人们对尼古丁对心肌肥大的影响了解甚少。本研究旨在探讨尼古丁在心肌细胞肥大中的作用及其潜在机制。

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《The Canadian journal of cardiology》 |2016年第10期|共10页
作者
Li Na; Si Biao; Ju Ji-Feng; Zhu Meng; You Feng; Wang Dong; Ren Jie; Ning Yan-Song; Zhang Feng-Quan; Dong Kai; Huang Jing; Yu Wen-Qian; Wang Tong-Jian; Qiao Bin;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
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1. Nicotine Induces Cardiomyocyte Hypertrophy Through TRPC3-Mediated Ca2+/NFAT Signalling Pathway [J] . Li Na, Si Biao, Ju Ji-Feng, The Canadian journal of cardiology . 2016,第10期

机译：尼古丁通过TRPC3介导的Ca2 + / NFAT信号通路诱导心肌肥大
2. PPARdelta activation inhibits angiotensin II induced cardiomyocyte hypertrophy by suppressing intracellular Ca2+ signaling pathway. [J] . Lee KS, Park JH, Lee S Journal of cellular biochemistry. . 2009,第5期

机译：PPARdelta激活通过抑制细胞内Ca2 +信号通路抑制血管紧张素II诱导的心肌肥大。
3. Telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the NFAT/ANP/BNP signaling pathway [J] . Li Xiurong, Lan Yuhuai, Wang Yan, Molecular medicine reports . 2017,第5aPta1期

机译：Telmisartan通过NFAT / ANP / BNP信号通路抑制心肌细胞凋亡来抑制心脏肥大
4. Cardiac Cell Hypertrophy In Vitro Role of Calcineurin/NFAT as Ca~(2+)Signal Integrators [C] . MATILDE COLELLA, TULLIO POZZAN Larry Horti Fairberg Workshop on Control and Regulation of Transport Phenomena in Biological Systems with Special Emphasis on the Cardiac System . 2008

机译：Carchineurin / NFAT作为CA〜（2+）信号积分器的心脏细胞肥大
5. Cellular and molecular mechanisms underlying nicotine induced upregulation of alpha 7 nicotinic acetylcholine receptor expressed in xenopus oocytes: The role of CA2+ and CA2+-dependent signaling pathways. [D] . Islam, Mohammad Faridul. 2015

机译：尼古丁诱导在非洲爪蟾卵母细胞中表达的α7烟碱乙酰胆碱受体上调的细胞和分子机制：CA2 +和CA2 +依赖性信号通路的作用。
6. Telmisartan suppresses cardiac hypertrophy by inhibiting cardiomyocyte apoptosis via the NFAT/ANP/BNP signaling pathway [O] . Xiurong Li, Yuhuai Lan, Yan Wang, -1

机译：替米沙坦通过NFAT / ANP / BNP信号通路抑制心肌细胞凋亡从而抑制心肌肥大
7. Aspirin Attenuates Angiotensin II-induced Cardiomyocyte Hypertrophy by Inhibiting the Ca2+/Calcineurin-NFAT Signaling Pathway [O] . Zheyu Yin, Xiaoyun Wang, Lan Zhang, 2016

机译：阿司匹林通过抑制CA2 + /钙肌蛋白-NFAT信号通路来抑制血管紧张素II诱导的心肌细胞肥大

Nicotine Induces Cardiomyocyte Hypertrophy Through TRPC3-Mediated Ca2+/NFAT Signalling Pathway

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