A fundamental problem of morphogenesis is whether it presents itself as a succession of links that are each driven by its own specific cause-effect relationship, or whether all of the links can be embraced by a common law that is possible to formulate in physical terms. We suggest that a common biophysical background for most, if not all, morphogenetic processes is based upon feedback between mechanical stresses (MS) that are imposed to a given part of a developing embryo by its other parts and MS that are actively generated within that part. The latter are directed toward hyper-restoration (restoration with an overshoot) of the initial MS values. We show that under mechanical constraints imposed by other parts, these tendencies drive forth development. To provide specificity for morphogenetic reactions, this feedback should be modulated by long-term parameters and/or initial conditions that are set up by genetic factors. The experimental and model data related to this concept are reviewed.
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