Delirium and Circadian Rhythm of Melatonin During Weaning From Mechanical Ventilation An Ancillary Study of a Weaning Trial

摘要

BACKGROUND: Delirium is frequent in patients in the ICU, but its association with the outcome of weaning from mechanical ventilation has not been assessed. Circadian rhythm alteration may favor delirium, in the current study we assessed the impact of delirium during weaning and associated alterations in the circadian rhythm of melatonin excretion.