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首页> 外文期刊>Chest: The Journal of Circulation, Respiration and Related Systems >Allergic bronchopulmonary aspergillosis after infliximab therapy for sarcoidosis: a potential mechanism related to T-helper cytokine balance.
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Allergic bronchopulmonary aspergillosis after infliximab therapy for sarcoidosis: a potential mechanism related to T-helper cytokine balance.

机译:英夫利昔单抗治疗结节病后的过敏性支气管肺曲菌病:与T辅助细胞因子平衡有关的潜在机制。

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摘要

We report a case of allergic bronchopulmonary aspergillosis (ABPA) that occurred in a man receiving infliximab for systemic sarcoidosis. His symptoms associated with ABPA were temporally related to his infliximab infusions. We suspect that infliximab disrupted the T-helper (Th) type 1-Th2 lymphocyte balance such that Th2 cytokines were left relatively unopposed, promoting the development of ABPA.
机译:我们报告一例发生过敏性支气管肺曲菌病(ABPA)的病例,该患者发生于因系统结节病而接受英夫利昔单抗治疗的男性。他与ABPA相关的症状在时间上与他的英夫利昔单抗输注有关。我们怀疑英夫利昔单抗破坏了T辅助(Th)型1-Th2淋巴细胞平衡,从而使Th2细胞因子相对不受阻,从而促进了ABPA的发展。

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