Molecular genetics of soft-tissue sarcomas: A brief overview for clinical oncologists

摘要

Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors with distinct lines of differentiation and biologic behavior. Currently, histological analysis is still the main diagnostic approach for the classification of STSs. However, ancillary molecular genetic methods are becoming increasingly important for diagnostic confirmation and therapeutic considerations. Herein, we provide a brief overview of clinically relevant molecular abnormalities of STSs for the general clinical oncologist.