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首页> 外文期刊>The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry >Facile formation of folic acid-modified dendrimer-stabilized gold-silver alloy nanoparticles for potential cellular computed tomography imaging applications
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Facile formation of folic acid-modified dendrimer-stabilized gold-silver alloy nanoparticles for potential cellular computed tomography imaging applications

机译:叶酸修饰的树枝状大分子稳定的金银合金纳米粒子的容易形成,可用于潜在的细胞计算机断层摄影成像应用

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摘要

We report a facile approach to fabricating dendrimer-stabilized gold-silver alloy nanoparticles (Au-Ag alloy DSNPs) for targeted in vitro computed tomography (CT) imaging of cancer cells. In this study, folic acid (FA)-modified amine-terminated generation 5 poly(amidoamine) dendrimers (G5·NH_2-FA) were used as stabilizers to prepare Au-Ag alloy DSNPs by simultaneously reducing both gold and silver salts, followed by acetylation of the dendrimer terminal amines. The formed Au-Ag alloy DSNPs were characterized via different techniques. We show that the formed Au-Ag alloy DSNPs are spherical in shape with a relatively narrow size distribution, have good water solubility and colloidal stability, and display higher X-ray attenuation intensity than the iodine-based contrast agent of Omnipaque at the same molar concentration of the active element (i.e., Au plus Ag, or iodine). Cytotoxicity assay results show that the Au-Ag alloy DSNPs are cytocompatible in a given concentration range. Importantly, the formed Au-Ag alloy DSNPs are able to be specifically taken up by cancer cells overexpressing FA receptors and enable targeted CT imaging of the cancer cells. Given the unique structural characteristics of dendrimers and the facile synthesis of DSNPs, the developed Au-Ag alloy DSNPs may be used for various biomedical applications in sensing, diagnosis, and therapeutics.
机译:我们报告了一种简便的方法来制造树枝状大分子稳定的金银合金纳米颗粒(Au-Ag合金DSNPs),用于癌细胞的靶向体外计算机断层扫描(CT)成像。在这项研究中,叶酸(FA)改性的胺封端的第5代聚(酰胺基胺)树状聚合物(G5·NH_2-FA)被用作稳定剂,通过同时还原金和银盐,然后制备金-银合金DSNP树状聚合物末端胺的乙酰化。形成的Au-Ag合金DSNP通过不同的技术进行了表征。我们表明,形成的Au-Ag合金DSNPs是球形的,具有相对窄的尺寸分布,具有良好的水溶性和胶体稳定性,并且在相同摩尔下比Omnipaque的碘基造影剂显示更高的X射线衰减强度活性元素(即金加银或碘)的浓度。细胞毒性测定结果表明,Au-Ag合金DSNP在给定的浓度范围内具有细胞相容性。重要的是,形成的Au-Ag合金DSNP能够被过表达FA受体的癌细胞特异性地吸收,并使癌细胞的靶向CT成像成为可能。鉴于树状聚合物的独特结构特征和DSNP的简便合成,开发的Au-Ag合金DSNP可用于传感,诊断和治疗中的各种生物医学应用。

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