4,6-Di-O-pentyl-3-O-trifluoroacetyl/propionyl cyclofructan stationary phases for gas chromatographic enantiomeric separations

摘要

4,6-Di-O-pentyl-3-O-trifluoroacetyl cycloinulohexaose (DP-TA-CF6) and 4,6-di-O-pentyl-3-O-propionyl cycloinulohexaose (DP-PN-CF6) were synthesized and used as chiral stationary phases (CSPs) in gas chromatography (GC). The chiral recognition ability of the two CSPs was investigated. A total of 47 racemic compounds were separated on the two new CSPs, including derivatized amino acids, amino alcohols, amines, alcohols, tartrates and lactones. Interestingly, several analytes were only separated on either the DP-TA-CF6 or the DP-PN-CF6 phase. The chiral recognition mechanism was evaluated through thermodynamic analysis. The result indicated there was no inclusion complex formation involved in the chiral recognition process.