Eight membered ethers via diene metathesis: Synthetic approach to laureatin natural products

摘要

Ruthenium-mediated diene metathesis is applied to the synthesis of a range of oxocenes. The methodology is then utilised for the preparation of prelaureatin analogues. A successful synthesis of the 8-desalkyl analogue of prelaureatin in enantiomerically enriched form is described. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 23]