Design and synthesis of a new type of modified nucleoside for triple helix-mediated adenine-thymine base pair recognition: Formation of hydrogen bonds to the far-side adenine

摘要

We have synthesized a new class of modified nucleoside, X, that could recognize adenine-thymine base pairs. They were designed to form the triple helix of A-T . X motif, where X forms hydrogen bonds to the N7 and NH2 of the far-side adenine in the major groove. Compounds 1 and 2 are a new type of tripler-forming modified nucleoside which are expected to act as DNA cleaving agents through the p-nitrophenyl group. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 12]