HIGHLY CONVENIENT ROUTE TO OPTICALLY PURE ALPHA-AMINOPHOSPHONIC ACIDS

摘要

Pure diasteriomers, obtained simply and directly by reaction of hypophosphorous acid salts of (R)(+) or (S)(-) - N-alpha-methylbenzylamine with aldehydes, can be simultaneously deprotected and oxidised in one step to provide a highly convenient synthesis of a aminophosphonic acids in high optical purity. [References: 18]