VERSATILE APPROACH TO THE SYNTHESIS OF GLOBOSIDE GLYCOSPHINGOLIPIDS - SYNTHESIS OF SIALYL-GALACTOSYL-GLOBOSIDE

摘要

Sialyl-galactosyl-globoside (SGG, 1), carrying the SSEA-4 antigen, is synthesized from readily available, versatile building blocks 2-7 in a convergent manner. Thus, appropriately protected tetra- and pentasaccharides 15 and 17 are generated, which constitute valuable intermediates for the synthesis of various other members of the globo-series of glycosphingolipids. [References: 22]