cis- and trans-3-Azido-oxetane-2-carboxylate scaffolds: hexamers of oxetane cis-#beta#-amino acids

摘要

Efficient synthesis of both cis- and trans-3-azido-oxetane-2-carboxylates relies upon efficient nucleophilic displacements of 3-O-triflates of oxetanes by trifluoroacetate and azide.Such structures are scaffolds for incorporation of oxetane-#beta#-amino acids into oligomers; the synthesis of a series of protected #beta#-hexapeptides and the X-ray crystal structure of emthyl 2,4-anhydro-6-deoxy-5-O-benzyl-L-altronate are reported.