First synthesis of blastidic acid, a component amino acid in an antibiotic, blasticidin S

摘要

Blastidic acid, a component amino acid inan antibiotic, blasticidin S, was synthesized for the first time from #alpha#,#gamma#-diaminobutyric acid. The synthesis was achieed through elongation of the carbon chain of the starting amino acid, and N-methylation and amidination of an #gamma#-amino group.