Direct asymmetric synthesis of oxazolines form olefins using a chiral nitridomanganese compelx:a novel three-component coupling leading to chiral oxazolines

摘要

A new synthetic method for chiral oxazolines has been developed by NI unit transfer to olefins using a chiral nitridomanganese complex.When trans-disubstittued styrenes were treated with chiral complex 1 in the presence of an acid chloride,oxazolines were obtained with high enantioselectivities (up to 92% ee).Furthermore,the produced oxazoliens could be easily converted into #beta#-aminoalcohols,which are ephedrine derivatives.