Novel carbohydrate scaffolds.Assembly of a uridine-mannose scaffold based on tunicamycin

摘要

A disaccharide scaffold based on tunicamycin was synthesized from D-uridine and L-mannose.The key step in disaccharide assembly was a #beta#-mannosylation performed using Crich's midification of the sulfoxide glycosylation method.The scaffold described contains two orthogonal derivatization sites and will be used in the search for novel biologically active compounds.