Solid phase synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids

Nefzi A.; Houghten RA.; Giulianotti MA.

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Solid phase synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids

机译：由N-酰化氨基酸固相合成1,6-二取代的2,3-二酮哌嗪和1,2-二取代的哌嗪

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The parallel synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from resin-bound reduced N-acylated amino acids is described. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 21]

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《Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry》 |1999年第49期|共4页
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Nefzi A.; Houghten RA.; Giulianotti MA.;
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正文语种 eng
中图分类有机化学;
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Combinatorial libraries; Drug discovery; Technologies; Chemistry;

机译：组合库;药物发现;技术;化学;

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1. Solid phase synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids [J] . Nefzi A., Houghten RA., Giulianotti MA. Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 1999,第49期

机译：由N-酰化氨基酸固相合成1,6-二取代的2,3-二酮哌嗪和1,2-二取代的哌嗪
2. Selective Synthesis of 2,3-Disubstituted-2H-isoindol-1-ylphosphonate and 2,3-Disubstituted-1,2-dihydroiso- quinolin-1-ylphosphonate via Metal-Tuned Reaction of α-Amino (2-Alkynylphenyl)methylphosphonate [J] . Qiuping Ding, Yang Ye, Renhua Fan, The Journal of Organic Chemistry . 2007,第14期

机译：通过α-氨基（2-炔基苯基）甲基膦酸酯的金属调谐反应选择性合成2,3-二取代-2H-异吲哚-1-基膦酸酯和2,3-二取代-1,2-二氢异喹啉-1-基膦酸酯
3. Solid-phase synthesis of 3,7-disubstituted perhydro-1,4-diazepine-2,5-diones from amino acids and #beta#-amino acids [J] . Jerome Giovannoni, Gilles Subra, Muriel Amblard, Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2001,第32期

机译：从氨基酸和＃beta＃-氨基酸固相合成3,7-二取代的过氢-1,4-二氮杂-2,5-二酮
4. Design and synthesis of cyclic alpha,alpha-disubstituted a-amino acids:1-Substituted 4-aminopiperidine-4-carboxylic acids [C] . Hiroshi Suemune, Makoto Oba, Yukiko Takano International Peptide Symposium;European Peptide Symposium . 2005

机译：环状α，α-二取代的A-氨基酸的设计与合成：1-取代的4-氨基哌啶-4-羧酸
5. Indane 2,5-diketopiperazine synthons as probes of solid, solution and gas phase supramolecular non-covalent associations: Synthesis, characterization, and analysis of indane amino acids, unnatural bis-amino esters, indane 2,5-diketopiperazines, and indane bis 2,5-diketopiperazines. [D] . Kloster, Robin A. 2003

机译：茚满2,5-二酮哌嗪合成子作为固相，溶液和气相超分子非共价键的探针：茚满氨基酸，非天然双氨基酯，茚满2,5-二酮哌嗪和茚满bis 2的合成，表征和分析，5-二酮哌嗪。
6. Design Synthesis and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating αα-Disubstituted Amino Acids with γ-Turn-Inducing Structures [O] . Yosuke Ota, Taeko Kakizawa, Yukihiro Itoh, 2018

机译：基于组蛋白H3肽的新型LSD1灭活剂的设计合成和体外评估该灭活剂整合了具有γ-转角诱导结构的αα-二取代氨基酸
7. Selective Synthesis of 2,3-Disubstituted-2H-isoindol-1-ylphosphonate and 2,3-Disubstituted-1,2-dihydroisoquinolin-1-ylphosphonate via Metal-Tuned Reaction of α-Amino (2-Alkynylphenyl)methylphosphonate. [O] . Qiuping Ding, Yang Ye, Renhua Fan, 2007

机译：通过α-氨基（2-炔基苯基）甲基膦酸酯的金属调速，选择性合成2,3-二取代-2H-异吲哚-1-苯基膦酸盐和2,3-二取代-1,2-二羟基喹啉-1-基膦酸盐。
8. Organolithium Routes to 1,2-Disubstituted Ethylene Derivatives. An Attempted Synthesis of 1,2-Dilithioethylene. [R] . Seyferth, D., Vick, S. C. 1977

机译：有机锂路由到1,2-二取代乙烯衍生物。试图合成1,2-二硫代乙烯。

Solid phase synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids

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