MURIHEXOCINS A AND B, TWO NOVEL MONO-THF ACETOGENINS WITH SIX HYDROXYLS, FROM ANNONA MURICATA (ANNONACEAE)

摘要

Two novel bioactive acetogenins, murihexocins A (1) and B (2), were isolated from the leaves of the sour sop tree, Annona muricata (Annonaceae). 1 and 2 are C-35 mono-tetrahydrofuran (THF) acetogenins having six hydroxyls, and their structures have been elucidated by spectroscopic analyses and derivations. No Annonaceous acetogenins having six hydroxyls or with two vicinal diol groups have been reported previously. 1 and 2 showed significant inhibitory effects among six human tumor cell lines with interesting selectivities to the prostate (PC-3) and pancreatic (PACA-2) cell lines. [References: 19]