Total synthesis of (-)-eburnamonine and (+)-epi-eburnamonine from a chiral non-racemic 4,4-disubstituted #gamma#-lactone

摘要

The total synthesis of (-)-eburnamonine and (+)-epi-eburnamonie was successfully achieved using a key chiral non-racemic 4,4-disubstituted #gamma#-lactone 4 that was prepared via the Rh(II) carbenoid mediated tertiary C-H insertion reaction of a chiral non-racemic diazomalonate 5.