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An improved synthesis of (-)-syringolides and X-ray structural characterization of synthetic (-)-syringolide 1

机译:(-)-丁香油精的合成方法改进和合成(-)-丁香油精1的X射线结构表征

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摘要

On treatment with 10% HF, butenolides 4a and 4b afforded enantiopure (-)-syringolides 1 (1a) and 2 (1b) respectively in much higher yields. Unprecedentedly, the cyclic acetal 5a was also converted to Ire by reacting with an excess of p-TsOH. The structure of the synthetic (-)-syringolide 1 (1a) was substantiated by an X-ray crystallographic study. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 11]
机译:在用10%HF处理时,丁烯内酯4a和4b分别以更高的产率获得对映体纯(-)-丁香油精1(1a)和2(1b)。前所未有地,环状乙缩醛5a也通过与过量的p-TsOH反应而转化为Ire。 X射线晶体学研究证实了合成的(-)-丁香油精1(1a)的结构。 (C)1998 Elsevier ScienceLtd。保留所有权利。 [参考:11]

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