(1S,3R,4R)-2-azanorbornyl-3-methanol oxazaborolidines in the asymmetric reduction of ketones

Pinho P.; Andersson PG.; Guijarro D.

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(1S,3R,4R)-2-azanorbornyl-3-methanol oxazaborolidines in the asymmetric reduction of ketones

机译：（1S，3R，4R）-2-氮杂降冰片基-3-甲醇恶唑硼烷在酮类化合物的不对称还原中的作用

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Synthesis of new rigid (1S, 3R, 4R)-2-azanorbornyl-3-methanols and its application in the asymmetric borane reduction of ketones are described. The influence of temperature, solvent and concentration on the reaction outcome were also studied and enantiomeric excess up to 89% could be obtained. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 23]

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《Tetrahedron》 |1998年第27期|共10页
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Pinho P.; Andersson PG.; Guijarro D.;
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中图分类有机化学;
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1. (1S,3R,4R)-2-azanorbornyl-3-methanol oxazaborolidines in the asymmetric reduction of ketones [J] . Pinho P., Andersson PG., Guijarro D. Tetrahedron . 1998,第27期

机译：（1S，3R，4R）-2-氮杂降冰片基-3-甲醇恶唑硼烷在酮类化合物的不对称还原中的作用
2. Effect of the Secondary Reduction on the Enantioselectivity and Function of Additives in the Chiral Oxazaborolidine-Catalyzed Asymmetric Borane Reduction of Ketones [J] . Han Liu, Da-Ming Du, Jiaxi Xu Helvetica chimica acta . 2006,第5期

机译：二次还原对手性恶唑硼烷催化的酮不对称硼烷还原反应中对映体选择性和添加剂功能的影响
3. Development of a new class of (1S,3R 4R)-2-azabicyclo[2.2.1]heptane-oxazoline ligands and their application in asymmetric transfer hydrogenation [J] . Trifonova A, Kallstrom KE, Andersson PG Tetrahedron . 2004,第15期

机译：新型（1S，3R 4R）-2-氮杂双环[2.2.1]庚烷-恶唑啉配体的开发及其在不对称转移加氢中的应用
4. On-chip detection of wild 3R, 4R and mutant 4R tau through kinesin-microtubule binding [C] . Subramaniyan S.P., Tarhan M.C., Karsten S.L., IEEE International Conference on Micro Electro Mechanical Systems . 2015

机译：通过驱动蛋白-微管结合对野生型3R，4R和突变型4R tau进行芯片检测
5. (3R,4S),(3S,4R) and (3R,4R),(3S,4S)-4-amino-5-fluoro-3-phenyl pentanoic acids as mechanism-based inactivators of 4-aminobutyric acid aminotransferase [D] . Nanavati, Shrenik M. 1988

机译：（3R，4S），（3S，4R）和（3R，4R），（3S，4S）-4-氨基-5-氟-3-苯基戊酸是基于机制的4-氨基丁酸氨基转移酶灭活剂
6. Design Synthesis and BiologicalEvaluation of (3R)-1234-Tetrahydro-7-hydroxy-N-(1S)-1-(3R4R)-4-(3-hydroxyphenyl)-34-dimethyl-1-piperidinylmethyl-2-methylpropyl-3-isoquinolinecarboxamide(JDTic) Analogues: In Vitro Pharmacology and ADME Profile [O] . Chad M. Kormos, MosesG. Gichinga, Rangan Maitra, -1

机译：设计合成与生物（3R）-1234-四氢-7-羟基-N-（1S）-1-（3R4R）-4-（3-羟基苯基）-34-二甲基）的评价-1-哌啶基甲基 -2-甲基丙基 -3-异喹啉羧酰胺（JDTic）类似物：体外药理学和ADME概况
7. Asymmetric ketone reduction using chiral oxazaborolidines derived from aziridine carbinols [O] . Johannes G.H. Willems, F. Jan Dommerholt, Jeannet B. Hammink, 1995

机译：使用衍生自氮葡萄氨基甲醇的手性恶唑啉酮的不对称酮还原
8. Selective Reductions. 45. Asymmetric Reduction of Prochiral Ketones by Iso-2-methyl, Iso-2-Ethyl, and (Iso-2(2-(Benzyloxy)Ethyl)Apopinocampheyl)-tert-Butylchloroboranes. Evidence for a Major Influence of the Steric Requirements of the 2-Substituent on the Efficiency of Asymmetric Reduction. [R] . Brown, H. C., Ramachandran, P. V. 1989

机译：选择性减少。 45.异-2-甲基，异-2-乙基和（异-2（2-（苄氧基）乙基）apopinocampheyl） - 叔丁基氯硼烷不对称还原前手性酮。 2-取代基的空间要求对不对称还原效率的主要影响的证据。

(1S,3R,4R)-2-azanorbornyl-3-methanol oxazaborolidines in the asymmetric reduction of ketones

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