Oxazaborolidine mediated asymmetric reduction of 1,2-diaryl-2-benzyloxyiminoethanones and 1,2-diarylethanediones

摘要

Highly enantioselective reduction of 1,2-diaryl-2-benzyloxyiminoethanones and 1,2-diarylethanediones was conducted using oxazaborolidine derived from L-threonine and borane complexes to give B-imino alcohols and 1,2-diaryl-1,2-ethanediols in high enantiomeric purity. Subsequent reduction of the imino functionality of the former products afforded either syn- or anti-2-amino-1,2-diarylethanols in high enantiomeric purity by choosing appropriate reduction methods. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 37]