Antileishmanial cyclic peroxides from the Palauan sponge Plakortis aff. angulospiculatus

摘要

As part of a program to discover new drugs for the treatment of tropical diseases, we have isolated and identified six new metabolites from the Palauan sponge Plakortis aff. angulospiculatus. Two cyclic peroxides show strong in vitro antiproliferative effects on promastigotes of Leishmania mexicana, a flagellate protozoan that causes leishmaniasis. The structures of the cyclic peroxides 1, 2 and 5 and furans 3, 4 and 6 were elucidated by interpretation of spectroscopic data, molecular modelling, and chemical interconversions. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 16]