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Effect of cyclohexenonic long chain fatty alcohols on neurite outgrowth. Study on structure-activity relationship

机译:环己烯基长链脂肪醇对神经突增生的影响。构效关系研究

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摘要

Four series of long chain fatty alcohols bearing a cyclohexenone moiety in addition to a omega-alkanol side chain were synthesized using "Umpolung" reactivity strategy. Their effect on neurite outgrowth was evaluated by means of fetal rat neurons in culture. The length of the omega-hydroxy side chain is a crucial factor for biological activity. (C) 1998 Elsevier Science Ltd. All rights reserved. [References: 27]
机译:使用“ Umpolung”反应性策略合成了除ω-烷醇侧链外还带有环己烯酮部分的四个系列的长链脂肪醇。通过培养中的胎鼠神经元评估它们对神经突生长的影响。 ω-羟基侧链的长度是生物活性的关键因素。 (C)1998 Elsevier ScienceLtd。保留所有权利。 [参考:27]

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