SOLID PHASE SYNTHESIS OF FUSED BICYCLIC AMINO ACID DERIVATIVES VIA INTRAMOLECULAR PAUSON-KHAND CYCLIZATION - VERSATILE SCAFFOLDS FOR COMBINATORIAL CHEMISTRY

摘要

Solution and solid phase synthetic methods leading to the rapid, stereocontrolled construction of highly functionalized fused bicyclic amino acid derivatives have been developed. The key step involves a unique application of the intramolecular Pauson-Khand cyclization for the construction of hexahydro-1H-[2]pyrindinone ring systems. Further modifications which demonstrate the potential for combinatorial library generation are also disclosed. (C) 1997 Published by Elsevier Science Ltd. [References: 41]