Calixarene amino acids; building blocks for calixarene peptides and peptide-dendrimers

摘要

A modular strategy towards receptor macromolecules is presented, which combines synthetically diverse peptide synthesis with highly functional calixarene chemistry. The design and synthesis of calix[4]arene amino acids 1a-f, calix-lysines, is described, which were used as construction blocks to assemble nanoscale, multivalent entities-calix-peptides 2 and calix-peptide-dendrimers 3. (C) 2003 Elsevier Ltd. All rights reserved. [References: 72]