(π-Allyl)palladium Complexes Bearing Diphosphinidenecyclobutene Ligands (DPCD): Highly Active Catalysts for Direct Conversion of Allylic Alcohols

摘要

The palladium-catalyzed allylation of carbon, oxygen, and nitrogen nucleophiles is a well established synthetic method. Given the numerous methods for the preparation of both racemic and enantiopure allylic alcohols, the palladium-catalyzed allylation represents a straightforward and efficient functionalization of allylic alcohols. Performance of this reaction relies on activation of the allylic alcohol as the carbonate, carboxylate, or numerous other good leaving groups. To date, methods to directly utilize allylic alcohols typically rely on the addition of a Lewis acid, such as Ti(O-iPr)_4. Use of a palladium catalyst to simultaneously perform the activation and subsequent reaction of the allylic alcohol would be an important contribution to this field.