Impact of Haplotype-Frequency Estimation Error on Test Statistics in Association Studies

摘要

Curtis and Sham (2006 [in this issue]) discuss the impact of haplotype-frequency estimation error on several statistics in case-control association studies. Of course, it is worth investigating how the error of haplotype-frequency estimation affects the results of association studies. However, to assess systematically the impact of haplotype-frequency estimation errors on association studies is not a trivial task. Here, we only consider some simple cases, to respond to the letter from Curtis and Sham (2006)