Total Synthesis of 16-Desmethylepothilone B, Epothilone B_10, Epothilone F, and Related Side Chain Modified Epothilone B Analogues

摘要

The macrolactonization-based strategy for the total synthesis of epothilones has been streamlined and imporved to a high level of efficiency and stereoslectivity. This strategy has been appled to the construction of vinyl iodide 19 which served as a common intermediate for the synthesis of a series of natural and designed epothilones including an epothilone B_10 (3), epothilone F (5), 16-desmethylepothilone B (14), pyridine epothilones 57a-57g, dimeric epothilones 59 and 61, and benzeoid epothilones 63a-63g.