Chernoenzymatic syntheses of (R)-2-bromo-, (R)-2-chloro- and (R)-2-azido-1-(1,3-benzodioxol-5-yl)-1-ethanol

摘要

Enantioselective reductions of 2-X-1-(1,3-benzodioxol-5-yl)-1-ethanones, (X = Cl, Br, N-3) by Rhodothorula glutinis CCT 2182 afforded the corresponding (R)-ethanols in good to excellent yields (57-99%) and excellent enantiomeric excesses (>99%). These alcohols may be used as raw materials for the preparation of the pharmaceuticals (R)-(-)-epinephrine, (R)-(-)-norepinephrine and (R)-(-)-isoproterenol. (C) 2004 Elsevier Ltd. All rights reserved.